CHRONIC CHEMOGENETIC ACTIVATION OF HIPPOCAMPAL PROGENITORS ENHANCES ADULT NEUROGENESIS AND MODULATES ANXIETY-LIKE BEHAVIOR AND FEAR EXTINCTION LEARNING

Adult hippocampal neurogenesis is a lifelong process that involves the integration of newborn neurons into the hippocampal network, and plays a role in cognitive function and the modulation of mood-related behavior.Here, we sought to address the impact of chemogenetic activation of adult hippocampal progenitors RCA Y Adapter on distinct stages of p

Peripheral nerve injuries occur as the result of sudden trauma and lead to reduced quality of life.The peripheral nervous system has an inherent capability to regenerate axons.However, peripheral nerve regeneration following injury is generally slow and incomplete that results in poor functional outcomes such as muscle atrophy.Although conventional

Context: DNA mismatch repair (MMR) deficiency (dMMR) testing is now recommended in endometrial cancer.Defect identification in the molecules participating in this pathway, or the presence of RCA Y Adapter microsatellite instability, are commonly employed for this purpose.Novel methods are continuously evolving to report dMMR/microsatellite instabil

Purpose.The use of anti-friction traction motor support bearings (TMSB) instead of plain friction traction motor support bearings is a priority direction of locomotive development both for newly constructed locomotives and for those in operation.The solution of the set tasks for introduction of wheel-motor blocks (WMB) with anti-friction bearings d